Yes, Sync'Em can help you get your iPhone sync'd wirelessly.

If you have an Exchange account that offers wireless syncing with your iPhone, just sync your Address Book and iCal to your Exchange account that syncs with your iPhone. Your Address Book contacts and iCal calendars can also be sync'd with your Google account and/or other Macs^*.

If you don't have an Exchange account that offers wireless syncing with your iPhone, you can get a hosted Exchange account that does offer wireless syncing then sync your Exchange account and/or Google account and/or Macs with that Exchange account (which then syncs wirelessly with your iPhone).

Our Exchange Hosting Providers page has some information on providers that offer wireless iPhone syncing.

^*Not all features are currently available. See the product roadmap for more information.